What is the catalog number for Anti-Hu CD77 FITC?

The catalog number for Anti-Hu CD77 FITC is 1F-193-T100.

What sizes are available for Anti-Hu CD77 FITC?

Anti-Hu CD77 FITC is available in the following size(s): 100 Tests.

Is Anti-Hu CD77 FITC in stock?

Anti-Hu CD77 FITC is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Anti-Hu CD77 FITC?

Anti-Hu CD77 FITC is manufactured by AFG-XBO.

What is the estimated delivery time for Anti-Hu CD77 FITC?

Estimated delivery time for Anti-Hu CD77 FITC is approximately 10 business day(s), depending on your location.

Anti-Hu CD77 FITC

CD77 (globotriaosylceramide Gb3), also known as the Pk blood group antigen, BLA (Burkitt´s lymphoma associated antigen), or CTH (ceramide trihexoside) is a neutral glycosphingolipid composed of three carbohydrate molecules linked to a lipid moiety in the cell membrane (Gal-alpha1-4Gal-beta1-4Glc-beta1-Cer) . It is expressed on germinal center B cells, Burkitt´s lymphoma cells, it can be induced on extrafolicular B cells and it is also found on endothelia and epithelia. CD77 may be involved in elimination of germinal center B cells that fail to produce high affinity antibodies, and serves also as receptor for shiga toxin and verotoxin.

Product Specifications

Certification

RUO

Reactivity

Human

Immunogen

Daudi cell line (Burkitt´s lymphoma)

Target Antigen

CD77

Clone

38.13

Applications

FC (QC tested)

Format

FITC

Buffer

Stabilizing Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide

References & Citations

*Högerkorp CM, Borrebaeck CA: The human CD77- B cell population represents a heterogeneous subset of cells comprising centroblasts, centrocytes, and plasmablasts, prompting phenotypical revision. J Immunol. 2006 Oct 1;177 (7) :4341-9., URL: http://www.ncbi.nlm.nih.gov/pubmed/16982868 , *Senda M, Ito A, Tsuchida A, Hagiwara T, Kaneda T, Nakamura Y, Kasama K, Kiso M, Yoshikawa K, Katagiri Y, Ono Y, Ogiso M, Urano T, Furukawa K, Oshima S, Furukawa K: Identification and expression of a sialyltransferase responsible for the synthesis of disialylgalactosylgloboside in normal and malignant kidney cells: downregulation of ST6GalNAc VI in renal cancers. Biochem J. 2007 Mar 15;402 (3) :459-70., URL: https://pubmed.ncbi.nlm.nih.gov/17123352/, *Taga S, Carlier K, Mishal Z, Capoulade C, Mangeney M, Lécluse Y, Coulaud D, Tétaud C, Pritchard LL, Tursz T, Wiels J: Intracellular signaling events in CD77-mediated apoptosis of Burkitt's lymphoma cells. Blood. 1997 Oct 1;90 (7) :2757-67., URL: https://pubmed.ncbi.nlm.nih.gov/9326243/, *Wiels J, Fellous M, Tursz T: Monoclonal antibody against a Burkitt lymphoma-associated antigen. Proc Natl Acad Sci U S A. 1981 Oct;78 (10) :6485-8., URL: https://www.ncbi.nlm.nih.gov/pubmed/7031655

Storage Conditions

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Specificity

The rat monoclonal antibody 38.13 recognizes CD77 (globotriaosylceramide Gb3), a neutral glycosphingolipid expressed mainly on the surface of B cell populations, such as germinal center B cells and Burkitt´s lymphoma cells.