What is the catalog number for Anti-Hu CD11b APC?

The catalog number for Anti-Hu CD11b APC is 1A-681-T100.

What sizes are available for Anti-Hu CD11b APC?

Anti-Hu CD11b APC is available in the following size(s): 100 Tests.

Is Anti-Hu CD11b APC in stock?

Anti-Hu CD11b APC is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Anti-Hu CD11b APC?

Anti-Hu CD11b APC is manufactured by AFG-XBO.

What is the estimated delivery time for Anti-Hu CD11b APC?

Estimated delivery time for Anti-Hu CD11b APC is approximately 10 business day(s), depending on your location.

Anti-Hu CD11b APC

CD11b (integrin alphaM subunit) is a 165-170 kDa type I transmembrane glycoprotein that non-covalently associates with integrin beta2 subunit (CD18) ; expression of the CD11b chain on the cell surface requires the presence of the CD18 antigen. CD11b/CD18 integrin (Mac-1, CR3) is highly expressed on NK cells, neutrophils, monocytes and less on macrophages. CD11b/CD18 integrin is implicated in various adhesive interactions of monocytes, macrophages and granulocytes, facilitating their diapedesis, as well as it mediates the uptake of complement coated particles, serving as a receptor for the iC3b fragment of the third complement component.

Product Specifications

Certification

RUO

Reactivity

Human, Non-human primates

Immunogen

Rheumatoid synovial cells and human monocytes.

Target Antigen

CD11b

Clone

ICRF44

Applications

FC (QC tested)

Format

APC

Buffer

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*Machacek C, Supper V, Leksa V, Mitulovic G, Spittler A, Drbal K, Suchanek M, Ohradanova-Repic A, Stockinger H: Folate Receptor β Regulates Integrin CD11b/CD18 Adhesion of a Macrophage Subset to Collagen. J Immunol. 2016 Sep 15;197 (6) :2229-38., URL: https://www.ncbi.nlm.nih.gov/pubmed/27534550 , *Hua J, Sakamoto K, Nagaoka I: Inhibitory actions of glucosamine, a therapeutic agent for osteoarthritis, on the functions of neutrophils. J Leukoc Biol. 2002 Apr;71 (4) :632-40., URL: https://www.ncbi.nlm.nih.gov/pubmed/11927650, *Sánchez-Torres C, García-Romo GS, Cornejo-Cortés MA, Rivas-Carvalho A, Sánchez-Schmitz G: CD16+ and CD16- human blood monocyte subsets differentiate in vitro to dendritic cells with different abilities to stimulate CD4+ T cells. Int Immunol. 2001 Dec;13 (12) :1571-81., URL: https://www.ncbi.nlm.nih.gov/pubmed/11717198, *Masten BJ, Olson GK, Tarleton CA, Rund C, Schuyler M, Mehran R, Archibeque T, Lipscomb MF: Characterization of myeloid and plasmacytoid dendritic cells in human lung. J Immunol. 2006 Dec 1;177 (11) :7784-93., URL: https://www.ncbi.nlm.nih.gov/pubmed/17114449, *Tieu BC, Lee C, Sun H, Lejeune W, Recinos A 3rd, Ju X, Spratt H, Guo DC, Milewicz D, Tilton RG, Brasier AR: An adventitial IL-6/MCP1 amplification loop accelerates macrophage-mediated vascular inflammation leading to aortic dissection in mice. J Clin Invest. 2009 Dec;119 (12) :3637-51., URL: https://www.ncbi.nlm.nih.gov/pubmed/19920349, *Rezzonico R, Imbert V, Chicheportiche R, Dayer JM: Ligation of CD11b and CD11c beta (2) integrins by antibodies or soluble CD23 induces macrophage inflammatory protein 1alpha (MIP-1alpha) and MIP-1beta production in primary human monocytes through a pathway dependent on nuclear factor-kappaB. Blood. 2001 May 15;97 (10) :2932-40., URL: https://www.ncbi.nlm.nih.gov/pubmed/11342414

Other References

*Hentzen ER, Neelamegham S, Kansas GS, Benanti JA, McIntire LV, Smith CW, Simon SI. Sequential binding of CD11a/CD18 and CD11b/CD18 defines neutrophil capture and stable adhesion to intercellular adhesion molecule-1. Blood. 2000 Feb 1;95 (3) :911-20., URL: https://pubmed.ncbi.nlm.nih.gov/10648403/, *Lawrence PK, Srikumaran S: CD11b of Ovis canadensis and Ovis aries: molecular cloning and characterization. Vet Immunol Immunopathol. 2007 Oct 15;119 (3-4) :287-98., URL: https://pubmed.ncbi.nlm.nih.gov/17628696/, *Akramiene D, Kondrotas A, Didziapetriene J, Kevelaitis E: Effects of beta-glucans on the immune system. Medicina (Kaunas) . 2007;43 (8) :597-606., URL: https://pubmed.ncbi.nlm.nih.gov/17895634/

Storage Conditions

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Specificity

The mouse monoclonal antibody ICRF44 recognizes an extracellular epitope of CD11b (Mac-1alpha), a 165-170 kDa type 1 transmembrane protein mainly expressed on monocytes, granulocytes and NK-cells.