Anti-Hu PDPN (cancer type) Purified
PDPN (podoplanin) is a type I transmembrane glycoprotein of mucin-type character. The specific function of this protein has not been determined, but its homologs in other species were described as differentiation antigens. PDPN can be used as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified.
Product Specifications
Certification
RUO
Reactivity
Human
Immunogen
Recombinant human PDPN
Target Antigen
PDPN (cancer type)
Clone
LpMab-23
Applications
WB, FC (QC tested), IHC
Concentration
1 mg/mL
Format
Purified
Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
*Miyazaki A, Nakai H, Sonoda T, Hirohashi Y, Kaneko MK, Kato Y, Sawa Y, Hiratsuka H: LpMab-23-recognizing cancer-type podoplanin is a novel predictor for a poor prognosis of early stage tongue cancer. Oncotarget 2018 Apr 20;9 (30) :21156-21165. , URL: https://pubmed.ncbi.nlm.nih.gov/29765527/, *Furusawa Y, Yamada S, Nakamura T, Sano M, Sayama Y, Itai S, Takei J, Harada H, Fukui M, Kaneko MK, Kato Y: PMab-235: A monoclonal antibody for immunohistochemical analysis against goat podoplanin. Heliyon 2019 Jul 10;5 (7) :e02063. doi: 10.1016/j.heliyon.2019.e02063, URL: https://pubmed.ncbi.nlm.nih.gov/31338471/
Storage Conditions
Store at 2-8°C. Do not freeze.
Specificity
The mouse monoclonal antibody LpMab-23 recognizes an extracellular epitope on human cancer type PDPN, a transmembrane glycoprotein, serving as a prognostic marker of oral carcinoma. This antibody recognizes an altered glycosylation pattern that occurs on oral cancer cells and it shows minimal reactivity with the surrounding non-cancerous tissue.
Applications Notes
Flow cytometry: Recommended dilution: 1-5 μg/ml.
Isotype
Mouse IgG1 kappa
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