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Anti-Hu PDPN (cancer type) Purified

PDPN (podoplanin) is a type I transmembrane glycoprotein of mucin-type character. The specific function of this protein has not been determined, but its homologs in other species were described as differentiation antigens. PDPN can be used as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified.

Product Specifications

Certification

RUO

Reactivity

Human

Immunogen

Recombinant human PDPN

Target Antigen

PDPN (cancer type)

Clone

LpMab-23

Applications

WB, FC (QC tested), IHC

Concentration

1 mg/mL

Format

Purified

Buffer

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*Miyazaki A, Nakai H, Sonoda T, Hirohashi Y, Kaneko MK, Kato Y, Sawa Y, Hiratsuka H: LpMab-23-recognizing cancer-type podoplanin is a novel predictor for a poor prognosis of early stage tongue cancer. Oncotarget 2018 Apr 20;9 (30) :21156-21165. , URL: https://pubmed.ncbi.nlm.nih.gov/29765527/, *Furusawa Y, Yamada S, Nakamura T, Sano M, Sayama Y, Itai S, Takei J, Harada H, Fukui M, Kaneko MK, Kato Y: PMab-235: A monoclonal antibody for immunohistochemical analysis against goat podoplanin. Heliyon 2019 Jul 10;5 (7) :e02063. doi: 10.1016/j.heliyon.2019.e02063, URL: https://pubmed.ncbi.nlm.nih.gov/31338471/

Storage Conditions

Store at 2-8°C. Do not freeze.

Specificity

The mouse monoclonal antibody LpMab-23 recognizes an extracellular epitope on human cancer type PDPN, a transmembrane glycoprotein, serving as a prognostic marker of oral carcinoma. This antibody recognizes an altered glycosylation pattern that occurs on oral cancer cells and it shows minimal reactivity with the surrounding non-cancerous tissue.

Applications Notes

Flow cytometry: Recommended dilution: 1-5 μg/ml.

Isotype

Mouse IgG1 kappa

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