What is the catalog number for Anti-HLA-C Purified?

The catalog number for Anti-HLA-C Purified is 11-896-C100.

What sizes are available for Anti-HLA-C Purified?

Anti-HLA-C Purified is available in the following size(s): 0.1 mg.

Is Anti-HLA-C Purified in stock?

Anti-HLA-C Purified is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Anti-HLA-C Purified?

Anti-HLA-C Purified is manufactured by AFG-XBO.

What is the estimated delivery time for Anti-HLA-C Purified?

Estimated delivery time for Anti-HLA-C Purified is approximately 10 business day(s), depending on your location.

Anti-HLA-C Purified

HLA-C, a member of MHC class I glycoproteins, is one of polymorphysm typing targets, which are important for transplantation. The HLA system plays an important role in the occurrence and outcome of infectious diseases. The structural spike and the nucleocapsid proteins of the novel coronavirus SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19), are reported to contain multiple Class I epitopes with predicted HLA restrictions. Individual HLA genetic variation may help explain different immune responses to a virus across a population. It has been described that HLA-C interacts with human herpesvirus 8 MIR1 protein.

Product Specifications

Certification

RUO

Reactivity

Non-human primates, Human

Immunogen

Purified MHC class I molecules of tamarin origin

Target Antigen

HLA-C

Clone

DT-9

Applications

IP, FC (QC tested)

Concentration

1 mg/mL

Format

Purified

Buffer

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*Körner C, Simoneau CR, Schommers P, Granoff M, Ziegler M, Hölzemer A, Lunemann S, Chukwukelu J, Corleis B, Naranbhai V, Kwon DS, Scully EP, Jost S, Kirchhoff F, Carrington M, Altfeld M: HIV-1-Mediated Downmodulation of HLA-C Impacts Target Cell Recognition and Antiviral Activity of NK Cells. Cell Host Microbe 2017 Jul 12;22 (1) :111-119. , URL: https://pubmed.ncbi.nlm.nih.gov/28704647/, *Tremante E, Lo Monaco E, Ingegnere T, Sampaoli C, Fraioli R, Giacomini P: Monoclonal antibodies to HLA-E bind epitopes carried by unfolded β2 m-free heavy chains . Eur J Immunol. 2015 Aug;45 (8) :2356-64., URL: https://pubmed.ncbi.nlm.nih.gov/25982269/, *Serena M, Parolini F, Biswas P, Sironi F, Blanco Miranda A, Zoratti E, Scupoli MT, Ziglio S, Valenzuela-Fernandez A, Gibellini D, Romanelli MG, Siccardi A, Malnati M, Beretta A, Zipeto D: HIV-1 Env associates with HLA-C free-chains at the cell membrane modulating viral infectivity. Sci Rep. 2018 May 22;8:46991. doi: 10.1038/srep46991. , URL: https://pubmed.ncbi.nlm.nih.gov/29786690/, *Corrah TW, Goonetilleke N, Kopycinski J, Deeks SG, Cohen MS, Borrow P, McMichael A, Brackenridge S: Reappraisal of the relationship between the HIV-1-protective single-nucleotide polymorphism 35 kilobases upstream of the HLA-C gene and surface HLA-C expression. J Virol. 2011 Apr;85 (7) :3367-74. , URL: https://pubmed.ncbi.nlm.nih.gov/21248048/, *van der Ploeg K, Chang C, Ivarsson MA, Moffett A, Wills MR, Trowsdale J: Modulation of human leukocyte antigen-C by human cytomegalovirus stimulates KIR2DS1 recognition by natural killer cells. Front Immunol. 2017 Mar 29;8:298. , URL: https://pubmed.ncbi.nlm.nih.gov/28424684/, *Parolini F, Biswas P, Serena M, Sironi F, Muraro V, Guizzardi E, Cazzoletti L, Scupoli MT, Gibellini D, Ugolotti E, Biassoni R, Beretta A, Malnati M, Romanelli MG, Zipeto D: Stability and expression levels of HLA-C on the cell membrane modulate HIV-1 infectivity. J Virol. 2017 Dec 14;92 (1) :e01711-17. , URL: https://pubmed.ncbi.nlm.nih.gov/29070683/

Storage Conditions

Store at 2-8°C. Do not freeze.

Specificity

The mouse monoclonal antibody DT-9 recognizes an extracellular epitope on HLA-C member of MHC class I molecules. It does not crossreact with HLA-A or HLA-B allotypes.