Anti-Hu Granzyme A Purified
Granzyme A is a serine protease expressed in the cytoplasmic granules of T cells and NK cells. Vectorial secretion of perforin and granzymes is responsible for their granule-mediated cytotoxicity. Similarly to granzyme B, granzyme A acts to destroy the target cells by proteolysis of their particular components. In case of granzyme A the targets are e.g. APEX1 (it destroys its oxidative repair activity), and nucleosome assembly protein SET (it disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA) .
Product Specifications
Certification
RUO
Immunogen
Full length human granzyme A
Target Antigen
Granzyme A
Clone
CB9
Applications
ICC, FC (QC tested), IP
Concentration
1 mg/mL
Format
Purified
Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
Storage Conditions
Store at 2-8°C. Do not freeze.
Specificity
The mouse monoclonal CB9 recognizes granzyme A, a 28 kDa serine protease expressed intracellularly in activated Tc cells and NK cells.
Applications Notes
Flow cytometry: Recommended dilution: 5-10 μg/ml, intracellular staining.
Species
Human
CAS Number
9007-83-4
Isotype
Mouse IgG1 kappa
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items