Anti-Hu CD172g Purified
CD172g is a transmembrane glycoprotein, which may play a role in inter-T cellular signaling by binding CD47, and thus in influencing T cell behaviour. CD172g is expressed on mature thymocytes, CD4+ T cells, CD8+ T cells, NK cells, and some B cells. It is absent on myeloid cells. Engagement of CD172g by CD47 expressed on antigen presenting cells results in enhanced antigen-specific T cell proliferation and costimulates T cell activation.
Product Specifications
Certification
RUO
Reactivity
Human
Immunogen
Recombinant human CD172g
Target Antigen
CD172g
Clone
OX-119
Applications
FC (QC tested), IP
Concentration
1 mg/mL
Format
Purified
Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
*Nettleship JE, Ren J, Rahman N, Berrow NS, Hatherley D, Barclay AN, Owens RJ: A pipeline for the production of antibody fragments for structural studies using transient expression in HEK 293T cells. Protein Expr Purif. 2008 Nov;62 (1) :83-9, URL: https://pubmed.ncbi.nlm.nih.gov/18662785/, *Brooke G, Holbrook JD, Brown MH, Barclay AN: Human lymphocytes interact directly with CD47 through a novel member of the signal regulatory protein (SIRP) family. J Immunol. 2004 Aug 15;173 (4) :2562-70 , URL: https://pubmed.ncbi.nlm.nih.gov/15294972/
Storage Conditions
Store at 2-8°C. Do not freeze.
Specificity
The mouse monoclonal antibody OX-119 recognizes an extracellular epitope on CD172g, an approximately 55 kDa transmembrane glycoprotein expressed on most T cells, as well as on NK cells and some B cell populations.
Applications Notes
Flow cytometry: Recommended dilution: 1-4 µg/ml
Isotype
Mouse IgG1
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