Anti-Hu CD119 Purified
CD119 (alpha subunit of interferon gamma receptor) is a type I transmembrane glycoprotein, which associates with IFNgammaAF1 to form functional receptor for interferon gamma, although CD119 alone is able to bind the cytokin. It is expressed on monocytes, macrophages, lymphocytes, NK cells, neutrophils, fibroblasts, epithelial and endothelial cells, as well as in many tumours.
Product Specifications
Certification
RUO
Reactivity
Human
Immunogen
CD119 purified from human placenta
Target Antigen
CD119
Clone
GIR-208
Applications
WB, FC (QC tested), IP
Concentration
1 mg/mL
Format
Purified
Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
*Fujii K, Miyahara Y, Harada N, Muraoka D, Komura M, Yamaguchi R, Yagita H, Nakamura J, Sugino S, Okumura S, Imoto S, Miyano S, Shiku H: Identification of an immunogenic neo-epitope encoded by murine sarcoma using CXCR3 ligand mRNAs as sensors. Oncoimmunology. 2017 Mar 20;6 (5) :e1306617., URL: https://pubmed.ncbi.nlm.nih.gov/28638727/?from_term=fujii+k+miyahara+y&from_pos=4, *Alavi S, Stewart AJ, Kefford RF, Lim SY, Shklovskaya E, Rizos H: Interferon signaling is frequently downregulated in melanoma. Front Immunol. 2018 Jun 21;9:1414. , URL: https://pubmed.ncbi.nlm.nih.gov/29977240/?from_term=alavi+s+kefford+rf&from_pos=1, *Crescioli C, Cosmi L, Borgogni E, Santarlasci V, Gelmini S, Sottili M, Sarchielli E, Mazzinghi B, Francalanci M, Pezzatini A, Perigli G, Vannelli GB, Annunziato F, Serio M: Methimazole inhibits CXC chemokine ligand 10 secretion in human thyrocytes. Endocrinol. 2007 Oct;195 (1) :145-55., URL: https://pubmed.ncbi.nlm.nih.gov/17911406/?from_term=crescioli+c+cosmi+l&from_pos=4, *Igarashi T, Teramoto K, Ishida M, Hanaoka J, Daigo Y: The mechanism of de novo expression of programmed cell death-ligand 1 in squamous cell carcinoma of the lung. Oncol Rep. 2017 Oct;38 (4) :2189-2196., URL: https://pubmed.ncbi.nlm.nih.gov/28791392/?from_term=igarashi+t+teramoto+k&from_pos=7, *Hoh A, Heeg M, Ni Y, Schuch A, Binder B, Hennecke N, Blum HE, Nassal M, Protzer U, Hofmann M, Urban S, Thimme R: Hepatitis B virus-infected HepG2hNTCP cells serve as a novel immunological tool to analyze the antiviral efficacy of CD8+ T cells in vitro. J Virol. 2015 Jul;89 (14) :7433-8., URL: https://pubmed.ncbi.nlm.nih.gov/25972537/?from_term=hoh+a+&from_pos=9, *El Darzi E, Bazzi S, Daoud S, Echtay KS, Bahr GM: Differential regulation of surface receptor expression, proliferation, and apoptosis in HaCaT cells stimulated with interferon-γ, interleukin-4, tumor necrosis factor-α, or muramyl dipeptide. Int J Immunopathol Pharmacol. 2017 Jun;30 (2) :130-145. , URL: https://pubmed.ncbi.nlm.nih.gov/28449603/?from_term=bazzi+s+&from_page=2&from_pos=1
Storage Conditions
Store at 2-8°C. Do not freeze.
Specificity
The mouse monoclonal antibody GIR-208 recognizes an epitope within extracellular part of CD119, a transmembrane glycoprotein of cytokine receptor family.
Applications Notes
Flow cytometry: Recommended dilution: 1-4 μg/ml.
Isotype
Mouse IgG1
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog