Anti-HDAC6 Purified

Histone deacetylase 6 (HDAC6), like other histone deacetylases, affects gene expression by regulation of chromatin remodeling. HDAC6 contains an internal duplication of two catalytic domains which appear to function independently of each other. Besides histones, HDAC6 deacetylates also other substrates including alpha tubulin and HSP90 alpha, and is involved in protein trafficking and degradation, as well as in affecting of cell shape and migration. Deregulation of HDAC6 expression and activity is associated with many diseases.

Product Specifications

Certification

RUO

Reactivity

Human

Immunogen

Human HDAC6

Target Antigen

HDAC6

Clone

178

Applications

ICC, ELISA, IP

Concentration

1 mg/mL

Format

Purified

Buffer

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Other References

*Seidel C, Schnekenburger M, Dicato M, Diederich M: Histone deacetylase 6 in health and disease. Epigenomics 2015; 7 (1) : 103-118., URL: https://www.ncbi.nlm.nih.gov/pubmed/25687470

Storage Conditions

Store at 2-8°C. Do not freeze.

Specificity

The mouse monoclonal antibody 178 recognizes zinc finger domain of human histone deacetylase 6 (HDAC6; an intracellular antigen) . Crossreactivity with other species was not tested.