Anti-HDAC6 Purified
Histone deacetylase 6 (HDAC6), like other histone deacetylases, affects gene expression by regulation of chromatin remodeling. HDAC6 contains an internal duplication of two catalytic domains which appear to function independently of each other. Besides histones, HDAC6 deacetylates also other substrates including alpha tubulin and HSP90 alpha, and is involved in protein trafficking and degradation, as well as in affecting of cell shape and migration. Deregulation of HDAC6 expression and activity is associated with many diseases.
Product Specifications
Certification
RUO
Negative Species
Mouse,Danio
Reactivity
Human
Immunogen
Human HDAC6
Target Antigen
HDAC6
Clone
159
Applications
WB, ICC, ELISA, FC (QC tested)
Concentration
1 mg/mL
Format
Purified
Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Other References
Storage Conditions
Store at 2-8°C. Do not freeze.
Specificity
The mouse monoclonal antibody 159 recognizes SE domain of human histone deacetylase 6 (HDAC6; an intracellular antigen), amino acids 971-981.
Applications Notes
Western blotting: Recommended dilution: 1-5 μg/ml.Immunocytochemistry: Recommended dilution: 5-10 μg/ml.
Isotype
Mouse IgG1 kappa
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