XPC-6444

XPC-6444 is a highly potent, isoform-selective, and CNS-penetrant NaV1.6 inhibitor (IC50=41 nM for hNaV1.6) . XPC-6444 also displays potent block of NaV1.2 (IC50=125 nM) . XPC-6444 shows anticonvulsant activity[1].

Product Specifications

CAS Number

[2230144-21-3]

UNSPSC

12352005

Target

Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/xpc-6444.html

Purity

98.93

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=S(C1=C(F)C=C(NCC2=C(F)C=CC=C2CN(C(C)(C)C)C)C=C1F)(NC3=CSC=N3)=O

Molecular Formula

C22H25F3N4O2S2

Molecular Weight

498.58

References & Citations

[1]Focken T, et al. Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective NaV1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy. J Med Chem. 2019 Oct 3.