XPC-6444
XPC-6444 is a highly potent, isoform-selective, and CNS-penetrant NaV1.6 inhibitor (IC50=41 nM for hNaV1.6) . XPC-6444 also displays potent block of NaV1.2 (IC50=125 nM) . XPC-6444 shows anticonvulsant activity[1].
Product Specifications
CAS Number
[2230144-21-3]
UNSPSC
12352005
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/xpc-6444.html
Purity
98.93
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=S(C1=C(F)C=C(NCC2=C(F)C=CC=C2CN(C(C)(C)C)C)C=C1F)(NC3=CSC=N3)=O
Molecular Formula
C22H25F3N4O2S2
Molecular Weight
498.58
References & Citations
[1]Focken T, et al. Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective NaV1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy. J Med Chem. 2019 Oct 3.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Nav1.2; Nav1.6
Available Sizes
Curated Selection
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