L-Histidine-15N3

L-Histidine-15N3 is the 15N-labeled L-Histidine. L-Histidine is an essential amino acid for infants. L-Histidine is an inhibitor of mitochondrial glutamine transport.

Product Specifications

CAS Number

[1217456-12-6]

UNSPSC

12352005

Target

Endogenous Metabolite; Isotope-Labeled Compounds; Mitochondrial Metabolism

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Others

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/l-histidine-15n3.html

Solubility

10 mM in DMSO

Smiles

OC([C@@H]([15NH2])CC1=C[15NH]C=[15N]1)=O

Molecular Formula

C6H9 15N3O2

Molecular Weight

158.13

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Bou Zeidan M, et al. L-histidine inhibits biofilm formation and FLO11-associated phenotypes in Saccharomyces cerevisiae flor yeasts. PLoS One. 2014 Nov 4;9 (11) :e112141.|[3]Rama Rao KV, et al. Brain edema in acute liver failure: inhibition by L-histidine. Am J Pathol. 2010 Mar;176 (3) :1400-8.|[4]Yoshikawa T, et al. Insufficient intake of L-histidine reduces brain histamine and causes anxiety-like behaviors in male mice. J Nutr. 2014 Oct;144 (10) :1637-41.