CCI-007

CCI-007 is a small molecule with cytotoxic activity against infant leukemia with MLL rearrangements, with IC50 values of 2.5-6.2 μM in sensitive cells[1].

Product Specifications

CAS Number

[939228-52-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cci-007.html

Purity

98.45

Solubility

DMSO : 83.33 mg/mL (ultrasonic)

Smiles

O=C(OCC)COC1=CC=C(/C=C(SC(N)=N2)\C2=O)C=C1OC

Molecular Formula

C15H16N2O5S

Molecular Weight

336.36

Precautions

H302, H315, H319, H335

References & Citations

[1]Klaartje Somers, et al. CCI-007, a novel small molecule with cytotoxic activity against infant leukemia with MLL rearrangements. Oncotarget. 2016 Jul 19;7 (29) :46067-46087.|[2]Klaartje Somers, et al. A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction. Oncogene. 2019 May;38 (20) :3824-3842.