Lofepramine
Lofepramine (Lopramine) is a modified tricyclic and orally active antidepressant. Lofepramine inhibits the uptake of Noradrenaline (NA) and 5-hydroxytryptamine (5-HT) with IC50s of 2.7 μM and 11 μM, respectively. Lofepramine exerts its antidepressant activity by promoting noradrenergic neurotransmission. Lofepramine also enhances serotonergic neurotransmission by inhibiting neuronal uptake of 5-HT and tryptophan pyrrolase. Lofepramine exhibits significant anxiolytic properties.[2][3][4].
Product Specifications
CAS Number
23047-25-8
Product Name Alternative
Lopramine
UNSPSC
12352005
Hazard Statement
H302, H335, H413
Target
5-HT Receptor; Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/lofepramine.html
Purity
99.0
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CN(CC(C1=CC=C(Cl)C=C1)=O)CCCN2C3=CC=CC=C3CCC4=CC=CC=C42
Molecular Formula
C26H27ClN2O
Molecular Weight
418.96
Precautions
H302, H335, H413
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
PKC mu (PRKD1) pSer910 Rabbit Polyclonal Antibody
Fas Ligand (FASLG) Human Gene Knockout Kit (CRISPR)
