S- (+) -Mecamylamine (hydrochloride)

S- (+) -Mecamylamine (hydrochloride) is a neuronal nicotinic receptor modulator with antidepressant activity.

Product Specifications

CAS Number

[107596-30-5]

Product Name Alternative

Dexmecamylamine (hydrochloride) ; TC-5214 (hydrochloride)

UNSPSC

12352211

Hazard Statement

H315, H319, H320

Target

NAChR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/s-plus-mecamylamine-hydrochloride.html

Purity

99.0

Solubility

10 mM in DMSO

Smiles

CN[C@]1([C@H]2C[C@H](CC2)C1(C)C)C.Cl

Molecular Formula

C11H22ClN

Molecular Weight

203.75

Precautions

H315, H319, H320

References & Citations

[1]Lippiello PM, Beaver JS, Gatto GJ, et al. TC-5214 (S- (+) -mecamylamine) : a neuronal nicotinic receptor modulator with antidepressant activity. CNS Neurosci Ther. 2008;14 (4) :266-277. |[2]Vieta E, Thase ME, Naber D, et al. Efficacy and tolerability of flexibly-dosed adjunct TC-5214 (dexmecamylamine) in patients with major depressive disorder and inadequate response to prior antidepressant. Eur Neuropsychopharmacol. 2014;24 (4) :564-574.