S- (+) -Mecamylamine (hydrochloride)
S- (+) -Mecamylamine (hydrochloride) is a neuronal nicotinic receptor modulator with antidepressant activity.
Product Specifications
CAS Number
107596-30-5
Product Name Alternative
Dexmecamylamine (hydrochloride) ; TC-5214 (hydrochloride)
UNSPSC
12352211
Hazard Statement
H315, H319, H320
Target
NAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/s-plus-mecamylamine-hydrochloride.html
Purity
99.0
Solubility
10 mM in DMSO
Smiles
CN[C@]1([C@H]2C[C@H](CC2)C1(C)C)C.Cl
Molecular Formula
C11H22ClN
Molecular Weight
203.75
Precautions
H315, H319, H320
References & Citations
[1]Lippiello PM, Beaver JS, Gatto GJ, et al. TC-5214 (S- (+) -mecamylamine) : a neuronal nicotinic receptor modulator with antidepressant activity. CNS Neurosci Ther. 2008;14 (4) :266-277. |[2]Vieta E, Thase ME, Naber D, et al. Efficacy and tolerability of flexibly-dosed adjunct TC-5214 (dexmecamylamine) in patients with major depressive disorder and inadequate response to prior antidepressant. Eur Neuropsychopharmacol. 2014;24 (4) :564-574.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
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