NFKBIA Antibody - N-terminal region
Product Specifications
CAS Number
9007-83-4
Gene Name
Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
Gene Aliases
IKBA, MAD-3, NFKBI, EDAID2
Gene ID
4792
Accession Number
NP_065390
Reactivity
Human, Pig
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human NFKBIA
Target
NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine) .
Partner Proteins
BTRC; NEDD9; IKBKB; CHUK; UBC; MTOR; IKBKG; SKP1; FBXW11; UBE2D3; RELA; NPLOC4; VCP; UFD1L; NFKB1; TNF; SUMO1; UBE2D1; COPS3; GPS1; SUMO3; Csnk2b; PRKCA; ST7; STAT1; REL; POLR2C; CD7; ARRB2; ARRB1; SUMO2; PSMA1; ZNF212; IKZF4; ATF4; TBK1; IKBKE; DNAJA3; S
Clonality
Polyclonal
Type
Polyclonal Antibody
Sequence
MFQAAERPQEWAMEGPRDGLKKERLLDDRHDSGLDSMKDEEYEQMVKELQ
Applications
WB, IHC
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Homology
Human: 100%; Pig: 76%
Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight
36kDa
Protein Length
317
NCBI Gene Symbol
NFKBIA
Host or Source
Rabbit
Protein Name
NF-kappa-B inhibitor alpha
Gene Name URL
NFKBIA
Nucleotide Accession Number
NM_020529
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
