TFAP2A Antibody - C-terminal region

Product Specifications

CAS Number

9007-83-4

Gene Name

Transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)

Gene Aliases

AP-2, BOFS, AP2TF, TFAP2, AP-2alpha

Gene ID

7020

Accession Number

NP_003211

Reactivity

Human, Mouse, Rat, Dog, Guinea Pig, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human TFAP2A

Target

TFAP2A is a sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limbs and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2 alpha is the only AP-2 protein required for early morphogenesis of the lens vesicleAP2-alpha is a 52-kD retinoic acid-inducible and developmentally regulated activator of transcription that binds to a consensus DNA-binding sequence CCCCAGGC in the SV40 and metallothionein (MIM 156350) promoters.[supplied by OMIM].

Partner Proteins

MKRN3; GSTO2; KCTD15; SUMO1; HECW2; SP1; BAG3; RB1; UBC; DAB2; Fcho2; EPAS1; SRA1; EPS15; KCTD1; EPN1; SH3BP4; UBE2I; AURKA; BRCA1; DNMT3A; ELAVL1; SUMO4; SUMO2; NPM1; YY1; PPARG; EPN2; CITED4; LDLRAP1; CITED2; EP300; MAGI1; WWP2; WWP1; HIP1; CASP6; CASP3

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

NLISHGFGSPAVCAAVTALQNYLTEALKAMDKMYLSNNPNSHTDNNAKSS

Applications

Purification

Protein A purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

1.0 mg/ml

Homology

Dog: 92%; Guinea Pig: 92%; Human: 100%; Mouse: 92%; Rabbit: 92%; Rat: 92%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

48kDa

Protein Length

437

NCBI Gene Symbol

TFAP2A

Host or Source

Rabbit

Protein Name

Transcription factor AP-2-alpha

Gene Name URL

TFAP2A

Nucleotide Accession Number

NM_003220

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