SMAD6 Antibody - N-terminal region
Product Specifications
CAS Number
9007-83-4
Gene Name
SMAD family member 6
Gene Aliases
AOVD2, MADH6, MADH7, HsT17432
Gene ID
4091
Accession Number
NP_005576
Reactivity
Human, Cow, Dog, Pig
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human SMAD6
Target
SMAD6 (mothers against decapentaplegic homolog 6) is an antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD.
Partner Proteins
ITCH; SMURF2; BPIFA1; NEDD4L; WWP2; WWP1; USP15; USP11; PIGR; NASP; LYZ; KPNA2; CTBP2; CTBP1; UBC; ACVR1; UBE2O; BAMBI; STAMBP; ACTR1B; TGFBR1; MYD88; SMAD1; BMPR2; BMPR1B; BMPR1A; ACVR2B; ACVR1B; SMURF1; PELI1; CUL2; ELAVL1; SMAD5; RPS6KA5; TSC22D1; MAPK
Clonality
Polyclonal
Type
Polyclonal Antibody
Sequence
GAPRDASDPLAGAALEPAGGGRSREARSRLLLLEQELKTVTYSLLKRLKE
Applications
WB
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Homology
Cow: 85%; Dog: 91%; Human: 100%; Pig: 85%
Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight
53kDa
Protein Length
496
NCBI Gene Symbol
SMAD6
Host or Source
Rabbit
Protein Name
Mothers against decapentaplegic homolog 6
Gene Name URL
SMAD6
Nucleotide Accession Number
NM_005585
Curated Selection
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