What is the catalog number for Manidipine?

The catalog number for Manidipine is HY-B0419.

What sizes are available for Manidipine?

Manidipine is available in the following size(s): 50 mg, 10 mM - 1 mL, 100 mg, 500 mg, 1 g.

How many pack sizes does Manidipine come in?

Manidipine is available in 5 different pack sizes.

Is Manidipine in stock?

Manidipine is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Manidipine?

Manidipine is manufactured by QuantiMol.

What is the estimated delivery time for Manidipine?

Estimated delivery time for Manidipine is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Manidipine?

The safety data sheet for Manidipine is available here: http://file.medchemexpress.com/batch_PDF/HY-B0419/Manidipine-SDS-MedChemExpress.pdf.

Manidipine

Manidipine is an orally active calcium channel antagonist. Manidipine regulates the expression of cytokines (IL-1β, IL-6) . Manidipine has a hypotensive effect. Manidipine can be used in the study of cardiovascular diseases (such as hypertension, myocardial ischemia-reperfusion injury, ventricular hypertrophy), kidney diseases (such as glomerular diseases), and epilepsy[1][2][3][4][5][6][7][8].

Product Specifications

CAS Number

89226-50-6

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Calcium Channel; Interleukin Related

Type

Reference compound

Related Pathways

Immunology/Inflammation; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Endocrinology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/manidipine.html

Purity

99.92

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=C(C)NC(C)=C(C(OC)=O)C1C2=CC=CC([N+]([O-])=O)=C2)OCCN3CCN(C(C4=CC=CC=C4)C5=CC=CC=C5)CC3

Molecular Formula

C35H38N4O6

Molecular Weight

610.70

Precautions

H302, H315, H319, H335

References & Citations

[1]Roth M, et al. Manidipine regulates the transcription of cytokine genes. Proc Natl Acad Sci U S A. 1992 May 1;89 (9) :4071-5.|[2]Huang S, et al. Manidipine inhibits endothelin-1-induced [Ca2+]i signaling but potentiates endothelin's effect on c-fos and c-jun induction in vascular smooth muscle and glomerular mesangial cells. Am Heart J. 1993 Feb;125 (2 Pt 2) :589-97.|[3]Costa S, et al. Manidipine reduces pro-inflammatory cytokines secretion in human endothelial cells and macrophages. Pharmacol Res. 2010 Sep;62 (3) :265-70.|[4]Yoshiyama M, et al. Effect of manidipine hydrochloride, a calcium antagonist, on isoproterenol-induced left ventricular hypertrophy. Jpn Circ J. 1998 Jan;62 (1) :47-52.|[5]Tojo A, et al. Effects of manidipine hydrochloride on the renal microcirculation in spontaneously hypertensive rats. J Cardiovasc Pharmacol. 1992 Dec;20 (6) :895-9.|[6]Rossoni G, et al. Combined simvastatin-manidipine protect against ischemia-reperfusion injury in isolated hearts from normocholesterolemic rats. Eur J Pharmacol. 2008 Jun 10;587 (1-3) :224-30.|[7]Haraguchi K, et al. Catalepsy induced by manidipine, a calcium channel blocker, in mice. J Pharm Pharmacol. 1996 Apr;48 (4) :429-32.|[8]Souza C N S, et al. 074— (SOA0068) Anticonvulsant activity of acute treatment with manidipine in pentylenetetrazole-and pilocarpine-induced seizure models in mice. Epilepsy & Behavior, 2014, 38: 214.