CYP1A1 inhibitor 8a

CYP1A1 inhibitor 8a is a compound that potently and selectively inhibits the CYP1A1 enzyme and has the potential to prevent cancer. CYP1A1 inhibitor 8a exhibits more than 10-fold selectivity for CYP1A1 and more than 100-fold selectivity over other enzymes in the CYP1 subfamily. CYP1A1 inhibitor 8a can effectively antagonize B[a]P-mediated activation of the aryl hydrocarbon receptor (AhR) in yeast cells and protect human cells from CYP1A1-mediated B[a]P toxicity. CYP1A1 inhibitor 8a has the potential to be developed as a cancer chemopreventive agent[1].

Product Specifications

CAS Number

[1821136-07-5]

UNSPSC

12352005

Target

HBV

Type

Reference compound

Related Pathways

Anti-infection

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cyp1a1-inhibitor-8a.html

Smiles

O=C(C1=CC=NC=C1)/C=C/C2=CC(OC)=C(OC)C(OC)=C2

Molecular Formula

C17H17NO4

Molecular Weight

299.32

References & Citations

[1] (E) -3- (3,4,5-Trimethoxyphenyl) -1- (pyridin-4-yl) prop-2-en-1-one, a heterocyclic chalcone is a potent and selective CYP1A1 inhibitor and cancer chemopreventive agent