MMP14 Recombinant Protein (Human)
Product Specifications
CAS Number
9000-83-3
Gene Name
Matrix metallopeptidase 14
Gene Aliases
Matrix metallopeptidase 14 (membrane-inserted) ; matrix metalloproteinase-14; membrane type 1 metalloprotease; Membrane-type matrix metalloproteinase 1; membrane-type-1 matrix metalloproteinase; MMP-14; MMP-X1; MT1MMP; MT1-MMP; MT-MMP; MT-MMP 1; MTMMP1; WNCHRS.
Gene ID
4323
Reactivity
Homo sapiens|Human
Target
Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development (By similarity) . May be involved in actin cytoskeleton reorganization by cleaving PTK7 (PubMed:20837484) . Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2 (PubMed:12714657) . Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis (PubMed:22330140) .
Type
Protein
Purification
Partially purified by single-step affinity chromatography and gel filtration.
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Bioactivity
‰¥70 U/µg. One U=100 pmol/min at 37°C using the colorimetric thiopeptolide Ac-Pro-Leu-Gly-S-Leu-LeuGly-OEt (100 µM) as substrate
Format
Liquid. In 50mM TRIS, pH 7.5, containing 5mM calcium chloride, 300mM sodium chloride, 20 uM zinc chloride, 0.5% Brij-35, and 30% glycerol.
Reconstitution
Store at -80C
Molecular Weight
65 kD
Protein Length
Recombinant
NCBI Gene Symbol
MMP14
Host or Source
E. Coli
Protein Name
Matrix metalloproteinase-14
Gene Name URL
MMP14
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