ZM241385-d7
ZM241385-d7 is a deuterated form of ZM241385. ZM241385 is a potent, high affinity and selective adenosine A2a receptor (A2AR) antagonist with a Ki value of 1.4 nM[1][2][3].
Product Specifications
UNSPSC
12352005
Target
Adenosine Receptor; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Solubility
10 mM in DMSO
Smiles
OC1=C([2H])C([2H])=C(CCNC2=NC3=NC(C4=C([2H])C([2H])=C([2H])O4)=NN3C(N)=N2)C([2H])=C1[2H]
Molecular Formula
C16H8D7N7O2
Molecular Weight
344.38
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Wang Z, et al. Static magnetic field exposure reproduces cellular effects of the Parkinson's disease drugcandidate ZM241385. PLoS One. 2010 Nov 8;5 (11) :e13883. |[3] Linden J, et al. Characterization of human A (2B) adenosine receptors: radioligandbinding, western blotting, and coupling to G (q) in human embryonickidney 293 cells and HMC-1 mast cells. Mol Pharmacol. 1999 Oct;56 (4) :705-13.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
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