Malformin A1
Malformin A1, a cyclic pentapeptide isolated from Aspergillus niger, possess a range of bioactive properties including antibacterial activity. Malformin A1 shows potent cytotoxic activities on human colorectal cancer cells. Malformin A1 induces apoptosis by activating PARP, caspase 3, -7, and -9[1].
Product Specifications
CAS Number
3022-92-2
UNSPSC
12352209
Hazard Statement
H301-H311-H331
Target
Apoptosis
Type
Peptides
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/malformin-a1.html
Solubility
10 mM in DMSO
Smiles
O=C1[C@@]([H])(NC([C@H](NC([C@@H](NC([C@@H]2NC([C@H](N1)CSSC2)=O)=O)C(C)C)=O)CC(C)C)=O)[C@H](CC)C
Molecular Formula
C23H39N5O5S2
Molecular Weight
529.72
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P403+P233-P405-P501
References & Citations
[1]Sun-Young Park, et al. Malformin A1 treatment alters invasive and oncogenic phenotypes of human colorectal cancer cells through stimulation of the p38 signaling pathway. Int J Oncol. 2017 Sep;51 (3) :959-966.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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