Malformin A1

Malformin A1, a cyclic pentapeptide isolated from Aspergillus niger, possess a range of bioactive properties including antibacterial activity. Malformin A1 shows potent cytotoxic activities on human colorectal cancer cells. Malformin A1 induces apoptosis by activating PARP, caspase 3, -7, and -9[1].

Product Specifications

CAS Number

[3022-92-2]

UNSPSC

12352209

Hazard Statement

H301-H311-H331

Target

Apoptosis

Type

Peptides

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/malformin-a1.html

Solubility

10 mM in DMSO

Smiles

O=C1[C@@]([H])(NC([C@H](NC([C@@H](NC([C@@H]2NC([C@H](N1)CSSC2)=O)=O)C(C)C)=O)CC(C)C)=O)[C@H](CC)C

Molecular Formula

C23H39N5O5S2

Molecular Weight

529.72

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P403+P233-P405-P501

References & Citations

[1]Sun-Young Park, et al. Malformin A1 treatment alters invasive and oncogenic phenotypes of human colorectal cancer cells through stimulation of the p38 signaling pathway. Int J Oncol. 2017 Sep;51 (3) :959-966.