PTPRN Recombinant Protein

Product Specifications

CAS Number

9000-83-3

Gene Name

Protein tyrosine phosphatase receptor type N

Gene Aliases

IA2; IA-2; IA-2/PTP; ICA 512; ICA512; insulinoma-associated tyrosine-phosphatase-like protein; islet cell antigen 2; islet cell antigen 512; islet cell autoantigen 3; protein tyrosine phosphatase-like N; PTP IA-2; receptor-type tyrosine-protein phosphatase-like N; R-PTP-N.

Gene ID

5798

Accession Number

NP_001186692.1

Reactivity

Homo sapiens|Human

Target

Plays a role in vesicle-mediated secretory processes (PubMed:24843546) . Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets (By similarity) . Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation (PubMed:24843546) . Plays a role in insulin secretion in response to glucose stimuli (PubMed:24843546) . Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain (By similarity) . In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (By similarity) . Required to maintain normal levels of renin expression and renin release (By similarity) . Seems to lack intrinsic enzyme activity (By similarity) . May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity) .

Conjugation

Unconjugated

Type

Protein

Source

E.coli

Applications

Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol