Palbociclib (Standard)

Palbociclib (Standard) is the analytical standard of Palbociclib. This product is intended for research and analytical applications. Palbociclib (PD 0332991) is an orally active selective CDK4 and CDK6 inhibitor with IC50 values of 11 and 16 nM, respectively. Palbociclib has potent anti-proliferative activity and induces cell cycle arrest in cancer cells, which can be used in the research of HR-positive and HER2-negative breast cancer and hepatocellular carcinoma[1][3][4].

Product Specifications

CAS Number

[571190-30-2]

Product Name Alternative

PD 0332991 (Standard)

UNSPSC

12352005

Hazard Statement

H341, H361, H373, H411

Target

CDK; Reference Standards

Type

Reference Standards

Related Pathways

Cell Cycle/DNA Damage; Others

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/palbociclib-standard.html

Purity

99.23

Smiles

O=C1C(C(C)=O)=C(C2=CN=C(N=C2N1C3CCCC3)NC4=CC=C(N5CCNCC5)C=N4)C

Molecular Formula

C24H29N7O2

Molecular Weight

447.53

Precautions

H341, H361, H373, H411

References & Citations

[1]Fry DW, et al. Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. Mol Cancer Ther. 2004 Nov;3 (11) :1427-38. |[2]Goel S, et al. CDK4/6 inhibition triggers anti-tumour immunity. Nature. 2017 Aug 24;548 (7668) :471-475. |[3]Richard S Finn, et al. PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro. Breast Cancer Res. 2009;11 (5) :R77. |[4]Bollard J, et al. Palbociclib (PD-0332991), a selective CDK4/6 inhibitor, restricts tumour growth in preclinical models of hepatocellular carcinoma. Gut. 2017 Jul;66 (7) :1286-1296.

Shipping Conditions

Blue Ice

Storage Conditions

4°C, sealed storage, away from light and moisture

Scientific Category

Reference Standards

Available Sizes

Curated Selection

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