Limaprost
Limaprost (OP1206) is a PGE1 analogue and a potent and orally active vasodilator. Limaprost increases blood flow and inhibits platelet aggregation. Limaprost pain relief, has antianginal effects, and can be used for ischaemic symptoms research[1][2].
Product Specifications
CAS Number
74397-12-9
Product Name Alternative
17α,20-dimethyl-δ2-PGE1; ONO1206; OP1206
UNSPSC
12352211
Hazard Statement
H300
Target
PGE synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Limaprost.html
Purity
99.91
Solubility
DMSO : ≥ 40 mg/mL
Smiles
O=C(O)/C=C/CCCC[C@@H]1[C@@H](/C=C/[C@@H](O)C[C@@H](C)CCCC)[C@H](O)CC1=O
Molecular Formula
C22H36O5
Molecular Weight
380.52
Precautions
H300
References & Citations
[1]Tsuboi T, et al. Pharmacological evaluation of OP 1206, a prostaglandin E1 derivative, as an antianginal agent. Arch Int Pharmacodyn Ther. 1980 Sep;247 (1) :89-102.|[2]Swainston Harrison T, et al. Limaprost. Drugs. 2007;67 (1) :109-18; discussion 119-20.|[3]Murata K, et al. PGE1 Attenuates IL-1β-induced NGF Expression in Human Intervertebral Disc Cells. Spine (Phila Pa 1976) . 2016 Jun;41 (12) :E710-6.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
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