L-Asparagine-4-13C (monohydrate)
L-Asparagine-4-13C monohydrate is the 13C-labeled L-Asparagine monohydrate.L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia[1][2][3][4][5][6].
Product Specifications
CAS Number
286437-12-5
Product Name Alternative
(-) -Asparagine-4-13C (monohydrate) ; Asn-4-13C (monohydrate) ; Asparamide-4-13C (monohydrate)
UNSPSC
12352211
Target
Apoptosis; DNA/RNA Synthesis; Endogenous Metabolite; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/l-asparagine-4-13c-monohydrate.html
Solubility
10 mM in DMSO
Smiles
N[13C](C[C@H](N)C(O)=O)=O.[H]O[H]
Molecular Formula
C3 13CH10N2O4
Molecular Weight
151.13
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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