NF2 Recombinant Protein
Product Specifications
CAS Number
9000-83-3
Gene Name
Neurofibromin 2
Gene Aliases
ACN; BANF; bilateral acoustic neurofibromatosis; merlin; merlin-1; moesin-ezrin-radixin like; moesin-ezrin-radixin-like protein; moesin-ezrin-radizin-like protein; neurofibromin 2 (bilateral acoustic neuroma) ; Neurofibromin-2; SCH; schwannomerlin; schwannomin.
Gene ID
4771
Accession Number
NP_000259.1
Reactivity
Homo sapiens|Human
Target
Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.
Conjugation
Unconjugated
Type
Protein
Source
E.coli
Applications
Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
700 ug/mL (prior to lyoph)
Format
Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
Reconstitution
2°C to 8°C|-80°C
Molecular Weight
30kDa
Protein Length
Recombinant
NCBI Gene Symbol
NF2
Host or Source
E.coli
Protein Name
Merlin
Gene Name URL
NF2
Nucleotide Accession Number
NM_000268.3
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MR214670L3V 200 µL
Gm44 (NM_001101450) Mouse Tagged ORF Clone Lentiviral Particle
Sign In for Pricing
View Details 
AMM08696G 0.1ml
Monoclonal TLE4 Antibody (Center), Clone: 384CT24.1.3.4
Sign In for Pricing
View Details ARP58522_P050-FITC 100 µL
RPL13A Antibody - middle region : FITC (ARP58522_P050-FITC)
Sign In for Pricing
View Details