CD177 Recombinant Protein
Product Specifications
CAS Number
9000-83-3
Gene Name
CD177 molecule
Gene Aliases
CD177 antigen; cell surface receptor; HNA-2a; HNA2A; human neutrophil alloantigen 2a; NB1; NB1 glycoprotein; NB1 GP; polycythemia rubra vera protein 1; PRV1; PRV-1.
Gene ID
57126
Accession Number
NP_065139.2
Reactivity
Homo sapiens|Human
Target
In association with beta-2 integrin heterodimer ITGAM/CD11b and ITGB2/CD18, mediates activation of TNF-alpha primed neutrophils including degranulation and superoxide production (PubMed:21193407) . In addition, by preventing beta-2 integrin internalization and attenuating chemokine signaling favors adhesion over migration (PubMed:28807980) . Heterophilic interaction with PECAM1 on endothelial cells plays a role in neutrophil transendothelial migration in vitro (PubMed:17580308) . However, appears to be dispensable for neutrophil recruitment caused by bacterial infection in vivo (PubMed:23461681) . Acts as a receptor for the mature form of protease PRTN3 allowing its display at the cell surface of neutrophils (PubMed:17244676, PubMed:18462208) . By displaying PRTN3 at the neutrophil cell surface, may play a role in enhancing endothelial cell junctional integrity and thus vascular integrity during neutrophil diapedesis (PubMed:23202369) .
Conjugation
Unconjugated
Type
Protein
Source
E.coli
Applications
Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
200 ug/mL (prior to lyoph)
Format
Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
Reconstitution
2°C to 8°C|-80°C
Molecular Weight
21.66kDa
Protein Length
Recombinant
NCBI Gene Symbol
CD177
Host or Source
E.coli
Protein Name
CD177 antigen
Gene Name URL
CD177
Nucleotide Accession Number
NM_020406.3
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
ABC-X1686 1 Vial
Xpress™ Human LACC1 Over-expressing Stable Cell Line
Sign In for Pricing
View Details MBS8803437-01 48 Well
Human RARg (Retinoic Acid Receptor Gamma) ELISA Kit
Sign In for Pricing
View Details MBS8803437-02 96 Well
Human RARg (Retinoic Acid Receptor Gamma) ELISA Kit
Sign In for Pricing
View Details MBS8803437-03 5x 96 Well
Human RARg (Retinoic Acid Receptor Gamma) ELISA Kit
Sign In for Pricing
View Details MBS8803437-04 10x 96 Well
Human RARg (Retinoic Acid Receptor Gamma) ELISA Kit
Sign In for Pricing
View Details 