PITRM1 Recombinant Protein
Product Specifications
CAS Number
9000-83-3
Gene Name
Pitrilysin metallopeptidase 1
Gene Aliases
Metalloprotease 1 (pitrilysin family) ; MP1; pitrilysin metalloproteinase 1; PreP; PreP peptidasome; presequence protease, mitochondrial; SCAR30.
Gene ID
10531
Accession Number
NP_001229236.1
Reactivity
Homo sapiens|Human
Target
Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing (PubMed:10360838, PubMed:16849325, PubMed:19196155, PubMed:24931469) . Has an ATP-independent activity (PubMed:16849325) . Specifically cleaves peptides in the range of 5 to 65 residues (PubMed:19196155) . Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference (PubMed:10360838, PubMed:19196155, PubMed:24931469) . Degrades the transit peptides of mitochondrial proteins after their cleavage (PubMed:19196155) . Also degrades other unstructured peptides (PubMed:19196155) . It is also able to degrade amyloid-beta protein 40, one of the peptides produced by APP processing, when it accumulates in mitochondrion (PubMed:16849325, PubMed:24931469) . It is a highly efficient protease, at least toward amyloid-beta protein 40 (PubMed:24931469) . Cleaves that peptide at a specific position and is probably not processive, releasing digested peptides intermediates that can be further cleaved subsequently (PubMed:24931469) .
Conjugation
Unconjugated
Type
Protein
Source
E.coli
Applications
Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
200 ug/mL (prior to lyoph)
Format
Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
Reconstitution
2°C to 8°C|-80°C
Molecular Weight
30kDa
Protein Length
Recombinant
NCBI Gene Symbol
PITRM1
Host or Source
E.coli
Protein Name
Presequence protease, mitochondrial
Gene Name URL
PITRM1
Nucleotide Accession Number
NM_001242307.1
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