LEPR Recombinant Protein
Product Specifications
CAS Number
9000-83-3
Gene Name
Leptin receptor
Gene Aliases
CD295; huB219; LEP-R; LEPRD; leptin receptor; OB receptor; OBR; OB-R.
Gene ID
3953
Accession Number
NP_001003679.1
Reactivity
Homo sapiens|Human
Target
Receptor for hormone LEP/leptin (Probable) (PubMed:22405007) . On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (By similarity) (PubMed:9537324) . In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity (PubMed:25060689, PubMed:12504075, PubMed:8805376) . Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis. Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus. Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T -ells. Leptin increases Th1 and suppresses Th2 cytokine production (By similarity) .
Conjugation
Unconjugated
Type
Protein
Source
E.coli
Applications
Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
200 ug/mL (prior to lyoph)
Format
Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
Reconstitution
2°C to 8°C|-80°C
Molecular Weight
32kDa
Protein Length
Recombinant
NCBI Gene Symbol
LEPR
Host or Source
E.coli
Protein Name
Leptin receptor
Gene Name URL
LEPR
Nucleotide Accession Number
NM_001003679.3
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS1243747-01 0.02 mg (E-Coli)
Recombinant Petrotoga mobilis UPF0296 protein Pmob_0099 (Pmob_0099)
Ask
View Details 
MBS1243747-02 0.1 mg (E-Coli)
Recombinant Petrotoga mobilis UPF0296 protein Pmob_0099 (Pmob_0099)
Ask
View Details MBS1243747-03 0.02 mg (Yeast)
Recombinant Petrotoga mobilis UPF0296 protein Pmob_0099 (Pmob_0099)
Ask
View Details MBS1243747-04 0.1 mg (Yeast)
Recombinant Petrotoga mobilis UPF0296 protein Pmob_0099 (Pmob_0099)
Ask
View Details MBS1243747-05 0.02 mg (Baculovirus)
Recombinant Petrotoga mobilis UPF0296 protein Pmob_0099 (Pmob_0099)
Ask
View Details MBS1243747-06 1 mg (E-Coli)
Recombinant Petrotoga mobilis UPF0296 protein Pmob_0099 (Pmob_0099)
Ask
View Details