IFNAR1 Recombinant Protein
Product Specifications
CAS Number
9000-83-3
Gene Name
Interferon (alpha and beta) receptor 1
Gene Aliases
I; If; Ifar; IFN-alpha/beta receptor 1; IFN-alpha/betaR; Ifnar; IFN-R-1; Ifrc; INF-a receptor; Infar; interferon alpha/beta receptor 1; type I interferon receptor 1.
Gene ID
15975
Accession Number
NP_034638.2
Reactivity
Mouse|Mus musculus
Target
Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:1533935, PubMed:14532120, PubMed:23872679) . Functions in general as heterodimer with IFNAR2 (By similarity) . Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (PubMed:14532120) . Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (PubMed:23872679) . Contributes to modulate the innate immune response to bacterial lipopolysaccharide (PubMed:23872679) .
Conjugation
Unconjugated
Type
Protein
Source
E.coli
Applications
Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
200 ug/mL (prior to lyoph)
Format
Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
Reconstitution
2°C to 8°C|-80°C
Molecular Weight
28kDa
Protein Length
Recombinant
NCBI Gene Symbol
Ifnar1
Host or Source
E.coli
Protein Name
Interferon alpha/beta receptor 1
Gene Name URL
Ifnar1
Nucleotide Accession Number
NM_010508.2
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