EPAS1 Recombinant Protein
Product Specifications
CAS Number
9000-83-3
Gene Name
Endothelial PAS domain protein 1
Gene Aliases
BHLHe7; bHLHe73; endothelial PAS domain-containing protein 1; EPAS-1; HIF; Hif like protein; HIF1 alpha-like factor; HIF1alpha-like factor; HIF-1-alpha-like factor; HIF-2; HIF2A; HIF2-alpha; HIF-2alpha; HIF-2-alpha; HIF-related factor; HL; HLF; HLF (HIF1alpha-like factor) ; HR; HRF; hypoxia inducible transcription factor 2alpha; hypoxia-inducible factor 2-alpha; mHLF; MO; MOP2.
Gene ID
13819
Accession Number
NP_034267.3
Reactivity
Mouse|Mus musculus
Target
Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (PubMed:26245371) . Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD (By similarity) .
Conjugation
Unconjugated
Type
Protein
Source
E.coli
Applications
Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
200 ug/mL (prior to lyoph)
Format
Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
Reconstitution
2°C to 8°C|-80°C
Molecular Weight
37kDa
Protein Length
Recombinant
NCBI Gene Symbol
Epas1
Host or Source
E.coli
Protein Name
Endothelial PAS domain-containing protein 1
Gene Name URL
Epas1
Nucleotide Accession Number
NM_010137.3
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