FGF1 Recombinant Protein
Product Specifications
CAS Number
9000-83-3
Gene Name
Fibroblast growth factor 1
Gene Aliases
Acidic fibroblast growth factor; aFGF; Dffrx; Fam; Fgf; Fgf-1; Fgf2b; Fgfa; fibroblast growth factor 1; fibroblast growth factor 1 (acidic) ; fibroblast growth factor 2b; HBGF-1; heparin-binding growth factor 1.
Gene ID
14164
Accession Number
NP_034327.1
Reactivity
Mouse|Mus musculus
Target
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1. Can induce angiogenesis.
Conjugation
Unconjugated
Type
Protein
Source
E.coli
Applications
Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
200 ug/mL (prior to lyoph)
Format
Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
Reconstitution
2°C to 8°C|-80°C
Molecular Weight
18kDa
Protein Length
Recombinant
NCBI Gene Symbol
Fgf1
Host or Source
E.coli
Protein Name
Fibroblast growth factor 1
Gene Name URL
Fgf1
Nucleotide Accession Number
NM_010197.3
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
143598-01 50 µg
Interleukin 12 (IL-12, Cytotoxic Lymphocyte Maturation Factor 1, CTL Maturation Factor (TcMF), Cytotoxic Lymphocyte Maturation Factor 35kD Subunit, CLMF p35, Natural Killer Cell Stimulatory Factor 1, NFSK1, p35, T cell Stimulating Factor, TSF) discontinued
Sign In for Pricing
View Details 143598-02 100 µg
Interleukin 12 (IL-12, Cytotoxic Lymphocyte Maturation Factor 1, CTL Maturation Factor (TcMF), Cytotoxic Lymphocyte Maturation Factor 35kD Subunit, CLMF p35, Natural Killer Cell Stimulatory Factor 1, NFSK1, p35, T cell Stimulating Factor, TSF) discontinued
Sign In for Pricing
View Details 
AM-1621Y-5 100 µg
Anti-Grapevine Fleck Virus (GFkV) IgG fraction monoclonal antibody (clone 4E3/C11)
Sign In for Pricing
View Details 