FCGR4 Recombinant Protein

Product Specifications

CAS Number

9000-83-3

Gene Name

Fc receptor, IgG, low affinity IV

Gene Aliases

4833442P21Rik; CD16-2; Fc fragment of IgG, low affinity IIIa, receptor for (CD16) ; Fc fragment of IgG, low affinity III, receptor for (CD16) ; Fc gammaRIV; Fc receptor-like 3; Fcgam; FcgammaRIV; Fcgr; Fcgr3a; FcgRIV; Fcrl3; low affinity immunoglobulin gamma Fc region receptor III-A; low affinity immunoglobulin gamma Fc region receptor IV.

Gene ID

246256

Reactivity

Mouse|Mus musculus

Target

Receptor for the Fc region of immunoglobulin gamma (PubMed:16039578) . Also acts as a receptor for the Fc region of immunoglobulin epsilon (PubMed:17558411, PubMed:18949059) . Binds with intermediate affinity to both IgG2a and IgG2b (PubMed:16039578, PubMed:17558411, PubMed:19795417) . Can bind to IgG2a and IgG2b monomers (PubMed:18949059) . Does not display binding to IgG1 or IgG3 (PubMed:16039578) . Mediates neutrophil activation by IgG complexes redundantly with Fcgr3 (PubMed:18097064) . Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a (PubMed:25824719) . Binds with low affinity to both the a and b allotypes of IgE (PubMed:18949059) . Has also been shown to bind to IgE allotype a only but not to allotype b (PubMed:17558411) . Binds aggregated IgE but not the monomeric form and bound monomeric IgG is readily displaced by IgE complexes (PubMed:18949059) . Binding to IgE promotes macrophage-mediated phagocytosis, antigen presentation to T cells, production of proinflammatory cytokines and the late phase of cutaneous allergic reactions (PubMed:17558411, PubMed:18949059) .

Conjugation

Unconjugated

Type

Protein

Source

E.coli

Applications

Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol