What is the catalog number for EIF2AK3 Recombinant Protein?

The catalog number for EIF2AK3 Recombinant Protein is OPCD02882-50UG.

What sizes are available for EIF2AK3 Recombinant Protein?

EIF2AK3 Recombinant Protein is available in the following size(s): 50 µg.

Is EIF2AK3 Recombinant Protein in stock?

EIF2AK3 Recombinant Protein is currently made to order / not held in immediate stock. Contact us for lead time.

What is the recommended dilution for this antibody?

A recommended dilution range for each validated application is provided on the datasheet, but optimal dilution should be titrated for your specific experimental system, sample type, and detection method.

What is the recommended storage temperature after reconstitution?

Post-reconstitution storage guidance is listed on the datasheet, typically requiring aliquoting and storage at -20°C or -80°C to preserve activity.

Can this product be used in multiplex assays?

Multiplex compatibility depends on the specific product and detection panel. Contact our technical support team with details of your multiplex system for guidance before ordering.

EIF2AK3 Recombinant Protein

Selected Variant

OPCD02882-50UG

Size: 50 µg

Product Specifications

CAS Number

9000-83-3

Gene Name

Eukaryotic translation initiation factor 2 alpha kinase 3

Gene Aliases

Eukaryotic translation initiation factor 2-alpha kinase 3; pancreatic eIF2-alpha kinase; PE; Pek; Perk; PRKR-like endoplasmic reticulum kinase.

Gene ID

13666

Accession Number

NP_001300847.1

Reactivity

Mouse|Mus musculus

Target

Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' during the unfolded protein response (UPR) and in response to low amino acid availability (PubMed:11106749) . Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor, leading to a reduced overall utilization of amino acids, or to a translation initiation activator of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion (PubMed:23921556) . Serves as a critical effector of unfolded protein response (UPR) -induced G1 growth arrest due to the loss of cyclin-D1 (CCND1) (PubMed:11035797) . Involved in control of mitochondrial morphology and function (PubMed:23921556) .

Conjugation

Unconjugated

Type

Protein

Source

E.coli

Applications

Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

200 ug/mL (prior to lyoph)

Format

Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.

Reconstitution

2°C to 8°C|-80°C

Molecular Weight

20kDa

Protein Length

Recombinant

NCBI Gene Symbol

Eif2ak3

Host or Source

E.coli

Protein Name

Eukaryotic translation initiation factor 2-alpha kinase 3

Gene Name URL

Eif2ak3

Nucleotide Accession Number

NM_001313918.1

Price

Frequently Asked Questions

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