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EGR1 Recombinant Protein

Product Specifications

CAS Number

9000-83-3

Gene Name

Early growth response 1

Gene Aliases

A530045N19Rik; early growth response protein 1; egr; Egr-; Egr-1; ETR10; ETR103; Krox; Krox-; Krox-1; Krox24; Krox-24; Krox-24 nuclear protein; nerve growth factor-induced protein A; NG; NGF; NGF1; NGF1-A; NGFIA; NGFI-A; TI; TIS8; transcription factor Zif268; Zen; Zenk; Zfp-; Zfp-6; Zif26; Zif268; zinc finger protein Krox-24.

Gene ID

13653

Accession Number

NP_031939.1

Reactivity

Mouse|Mus musculus

Target

Transcriptional regulator (PubMed:8336701, PubMed:8703054, PubMed:15958557) . Recognizes and binds to the DNA sequence 5'-GCG (T/G) GGGCG-3' (EGR-site) in the promoter region of target genes (PubMed:8703054, PubMed:15958557, PubMed:2028256, PubMed:8939742) . Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity) . Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia (PubMed:11100120, PubMed:15958557) . Plays a role in the regulation of cell survival, proliferation and cell death (PubMed:15265859, PubMed:15958557) . Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation (PubMed:15958557) . Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy (PubMed:15265859) . Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia (PubMed:11100120) . Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (PubMed:8703054) .

Conjugation

Unconjugated

Type

Protein

Source

E.coli

Applications

Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

200 ug/mL (prior to lyoph)

Format

Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.

Reconstitution

2°C to 8°C|-80°C

Molecular Weight

22/27kDa

Protein Length

Recombinant

NCBI Gene Symbol

Egr1

Host or Source

E.coli

Protein Name

Early growth response protein 1

Gene Name URL

Egr1

Nucleotide Accession Number

NM_007913.5

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