CTTN Recombinant Protein

Product Specifications

CAS Number

9000-83-3

Gene Name

Cortactin

Gene Aliases

Cttnb; src substrate cortactin.

Gene ID

60465

Accession Number

NP_068640.2

Reactivity

Rat|Rattus norvegicus

Target

Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:18768925) . Plays a role in the formation of lamellipodia and in cell migration (PubMed:18768925) . Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (PubMed:21210813) . Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity) . Plays a role in the invasiveness of cancer cells, and the formation of metastases (By similarity) . Plays a role in focal adhesion assembly and turnover (PubMed:18768925, PubMed:22952866) . In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P) -mediated endothelial cell (EC) barrier enhancement (By similarity) . Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (By similarity) . Plays a role in receptor-mediated endocytosis via clathrin-coated pits (PubMed:12612086, PubMed:19995918) . Required for stabilization of KCNH1 channels at the cell membrane (By similarity) .

Conjugation

Unconjugated

Type

Protein

Source

E.coli

Applications

Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol