CTTN Recombinant Protein
Product Specifications
CAS Number
9000-83-3
Gene Name
Cortactin
Gene Aliases
Cttnb; src substrate cortactin.
Gene ID
60465
Accession Number
NP_068640.2
Reactivity
Rat|Rattus norvegicus
Target
Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:18768925) . Plays a role in the formation of lamellipodia and in cell migration (PubMed:18768925) . Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (PubMed:21210813) . Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity) . Plays a role in the invasiveness of cancer cells, and the formation of metastases (By similarity) . Plays a role in focal adhesion assembly and turnover (PubMed:18768925, PubMed:22952866) . In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P) -mediated endothelial cell (EC) barrier enhancement (By similarity) . Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (By similarity) . Plays a role in receptor-mediated endocytosis via clathrin-coated pits (PubMed:12612086, PubMed:19995918) . Required for stabilization of KCNH1 channels at the cell membrane (By similarity) .
Conjugation
Unconjugated
Type
Protein
Source
E.coli
Applications
Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
200 ug/mL (prior to lyoph)
Format
Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
Reconstitution
2°C to 8°C|-80°C
Molecular Weight
76kDa
Protein Length
Recombinant
NCBI Gene Symbol
Cttn
Host or Source
E.coli
Protein Name
Src substrate cortactin
Gene Name URL
Cttn
Nucleotide Accession Number
NM_021868.2
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