NPPB
NPPB is a blocker of the outwardly rectifying chloride channel (ORCC) .
Product Specifications
CAS Number
[107254-86-4]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Chloride Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/NPPB.html
Purity
99.78
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)C1=CC([N+]([O-])=O)=CC=C1NCCCC2=CC=CC=C2
Molecular Formula
C16H16N2O4
Molecular Weight
300.31
Precautions
H302, H315, H319, H335
References & Citations
[1]Li J, et al. Enhancement of an outwardly rectifying chloride channel in hippocampal pyramidal neurons after cerebral ischemia. Brain Res. 2016 Aug 1;1644:107-17.|[2]Park M, et al. Double Blockade of Glioma Cell Proliferation and Migration by Temozolomide Conjugated withNPPB, a Chloride Channel Blocker. ACS Chem Neurosci. 2016 Mar 16;7 (3) :275-85.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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