AIMP1 Recombinant Protein

Product Specifications

CAS Number

9000-83-3

Gene Name

Aminoacyl tRNA synthetase complex interacting multifunctional protein 1

Gene Aliases

Aminoacyl tRNA synthase complex-interacting multifunctional protein 1; ARS-interacting multifunctional protein 1; EMAP2; EMAPII; endothelial monocyte-activating polypeptide 2; endothelial-monocyte activating polypeptide II; HLD3; multisynthase complex auxiliary component p43; multisynthetase complex auxiliary component p43; p43; SCYE1; small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating) .

Gene ID

9255

Accession Number

NP_001135887.1

Reactivity

Homo sapiens|Human

Target

Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase (PubMed:10358004) . Binds tRNA. Possesses inflammatory cytokine activity (PubMed:11306575) . Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation (By similarity) . Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels (By similarity) . Promotes dermal fibroblast proliferation and wound repair (PubMed:16472771) . Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum (By similarity) . Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations (PubMed:12237313) . Induces maturation of dendritic cells and monocyte cell adhesion (PubMed:11818442) . Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7 (PubMed:19362550) .

Conjugation

Unconjugated

Type

Protein

Source

E.coli

Applications

Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol