SYD5115
SYD5115 is an orally available TSH-R antagonist[1][2].
Product Specifications
UNSPSC
12352005
Target
TSH Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/syd5115.html
Purity
99.69
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O[C@H](C(C)(C)C)C)NC1=NC=C(N(C(C)=O)C2(C)C)C(C32CCC(F)(F)CC3)=N1
Molecular Formula
C22H32F2N4O3
Molecular Weight
438.51
References & Citations
[1]Karstens WFJ, et al. Discovery of SYD5115, a novel orally active small molecule TSH-R antagonist. Bioorg Med Chem. 2023 Apr 15;84:117258.|[2]Furmaniak J, et al. In vivo effects of a human thyroid-stimulating monoclonal autoantibody (M22) and a human thyroid-blocking autoantibody (K1-70) . Auto Immun Highlights. 2011 Sep 14;3 (1) :19-25.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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