TOPBP1 Recombinant Protein
Product Specifications
CAS Number
9000-83-3
Gene Name
Topoisomerase (DNA) II binding protein 1
Gene Aliases
1110031N14Rik;2810429C13Rik; AI256758; D430026L04Rik; DNA topoisomerase 2-binding protein 1; DNA topoisomerase II-beta-binding protein 1; DNA topoisomerase II-binding protein 1; mKIAA0259; topoisomerase (DNA) II beta binding protein.
Gene ID
235559
Accession Number
NP_795953.2
Reactivity
Mouse|Mus musculus
Target
Required for DNA replication (By similarity) . Plays a role in the rescue of stalled replication forks and checkpoint control (PubMed:14718568) . Binds double-stranded DNA breaks and nicks as well as single-stranded DNA (By similarity) . Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage (By similarity) . Induces a large increase in the kinase activity of ATR (By similarity) .
Conjugation
Unconjugated
Type
Protein
Source
E.coli
Applications
Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
200 ug/mL (prior to lyoph)
Format
Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
Reconstitution
2°C to 8°C|-80°C
Molecular Weight
32kDa
Protein Length
Recombinant
NCBI Gene Symbol
Topbp1
Host or Source
E.coli
Protein Name
DNA topoisomerase 2-binding protein 1
Gene Name URL
Topbp1
Nucleotide Accession Number
NM_176979.5
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