Cetalkonium (chloride)

Cetalkonium chloride is an ammonium antiseptic agent used in many topical agents for infections of mouth, throat and eye. Cetalkonium chloride acts as anti-inflammatory amphiphilic agent. Cetalkonium chloride is a cationic surfactant, that improves the precorneal residence time and bioavailability of drugs. Cetalkonium chloride interacts with the negative charges on the bacterial cell membrane, disrupts the integrity of the cell membrane, causes leakage of cell contents and ultimately leading to bacterial death[1][2][3].

Product Specifications

CAS Number

[122-18-9]

Product Name Alternative

Benzyldimethylhexadecylammonium (chloride)

UNSPSC

12352005

Hazard Statement

H302+H312, H314, H400

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cetalkonium-chloride.html

Purity

99.42

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[N+](C)(CCCCCCCCCCCCCCCC)CC1=CC=CC=C1.[Cl-]

Molecular Formula

C25H46ClN

Molecular Weight

396.09

Precautions

H302+H312, H314, H400

References & Citations

[1]Cesar Torres-Luna, et al. Formation of Drug-Participating Catanionic Aggregates for Extended Delivery of Non-Steroidal Anti-Inflammatory Drugs from Contact Lenses. Biomolecules. 2019 Oct 10;9 (10) :593.|[2]Daull P, et al., Benefits of cetalkonium chloride cationic oil-in-water nanoemulsions for topical ophthalmic drug delivery. J Pharm Pharmacol. 2014 Apr;66 (4) :531-41.|[3]Amangeldykyzy S, et al. The effect of a combined choline salicylate and cetalkonium chloride gel on particular strains of Pseudomonas aeruginosa, Staphylococcus spp. and Streptococcus spp[J]. Current Issues in Pharmacy and Medical Sciences, 2015, 28 (2) : 78-80.