Eicosapentaenoyl ethanolamide-d4

Eicosapentaenoyl ethanolamide-d4 is the deuterium labeled Eicosapentaenoyl ethanolamide. Eicosapentaenoyl ethanolamide, an omega-3 fatty acid, is one of N-acylethanolamines (NAEs) . Eicosapentaenoyl ethanolamide is cannabinoid CB1/CB2 receptor agonist. Eicosapentaenoyl ethanolamide acts as a metabolic signal. Eicosapentaenoyl ethanolamide inhibits dietary restriction (DR) -induced lifespan extension in wild type animals and suppresses lifespan extension in a TOR pathway mutant[1][2].

Product Specifications

CAS Number

[946524-41-0]

UNSPSC

12352211

Hazard Statement

H225, H319

Target

Cannabinoid Receptor; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others

Field of Research

Metabolic Disease

Concentration

2.86 mM * 500 μL in Ethanol

Purity

99.0

Solubility

10 mM in DMSO

Smiles

CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(NC([2H])([2H])C([2H])([2H])O)=O

Molecular Formula

C22H31D4NO2

Molecular Weight

349.54

Precautions

H225, H319

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Mark Lucanic, et al. N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegans. Nature. 2011 May 12;473 (7346) :226-9.|[3]Iain Brown, et al. Cannabinoid receptor-dependent and -independent anti-proliferative effects of omega-3 ethanolamides in androgen receptor-positive and -negative prostate cancer cell lines. Carcinogenesis. 2010 Sep;31 (9) :1584-91.