L-741671
L-741671 is a selective and brain-permeable antagonist of neurokininl (hNKI) receptor, with Kis of 64 nM, 0.03 nM and 0.7 nM in rat, human and ferret, respectively[1].
Product Specifications
CAS Number
187724-85-2
UNSPSC
12352005
Target
Neurokinin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Endocrinology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/l-741671.html
Smiles
O=C1NNC(CN2[C@@H]([C@@H](CCC2)OCC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)C4=CC=CC=C4)=N1
Molecular Formula
C23H22F6N4O2
Molecular Weight
500.44
References & Citations
[1]F D Tattersall, et al. Tachykinin NK1 receptor antagonists act centrally to inhibit emesis induced by the chemotherapeutic agent cisplatin in ferrets. Neuropharmacology. 1996;35 (8) :1121-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NK1R
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