MBNL1 Recombinant Protein
Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. Binds to the st-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assbly. Binds to the 5'-YGCU (U/G) Y-3'consensus sequence. Binds to the IR RNA. Binds to expanded CUG repeat RNA, which folds into a hairpin structure containing GC base pairs and bulged, unpaired U residues.
Product Specifications
CAS Number
9000-83-3
Gene Name
Muscleblind like splicing regulator 1
Gene Aliases
EXP; MBNL; muscleblind-like; muscleblind-like protein 1; triplet-expansion RNA-binding protein.
Gene ID
4154
Accession Number
NP_001300986.1
Reactivity
Homo sapiens|Human
Target
Type
Protein
Source
E.coli
Sequence
Purification
Affinity purified using IMAC
Assay Protocol
Format
Liquid or Lyophilized powder
Reconstitution
-20°C or -80°C
Molecular Weight
57 kDa
Protein Length
Recombinant
NCBI Gene Symbol
MBNL1
Host or Source
Human
Protein Name
Muscleblind-like protein 1
Gene Name URL
MBNL1
Nucleotide Accession Number
NM_001314057.1
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