MMs02943764
MMs02943764 is a 1,2,4-triazole derivative with anticancer activity. MMs02943764 has significant antiproliferative effects on multiple cancer cell lines. PAC, a structural analog of MMs02943764, has significant cytotoxicity against the leukemia cell line K562 (IC50=35.264 μM), reduces the degradation of p53 by inhibiting Mdm2 and Pirh2, and induces K562 cell cycle arrest[1].
Product Specifications
CAS Number
708287-29-0
UNSPSC
12352005
Target
MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mms02943764.html
Purity
98.0
Smiles
O=C(CSC1=NN=C(COC2=CC(C)=CC=C2C(C)C)N1CC=C)NC3=C(Br)C=C(F)C=C3F
Molecular Formula
C24H25BrF2N4O2S
Molecular Weight
551.45
References & Citations
[1]Niazi, et al. "Synthesis, characterization, and anti-cancer potential of novel p53-mediated Mdm2 and Pirh2 modulators: an integrated In silico and In vitro approach." Frontiers in Chemistry 12 (2024) : 1366370.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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