Pro-GA
Pro-GA is a γ-Glutamylcyclotransferase (GGCT) inhibitor and a cell-permeable diester-type pro-drug with anticancer activity, GGCT is a key enzyme in glutathione metabolism and is involved in the ferroptosis pathway. Pro-GA exhibits an IC50 of 57 μM against the bladder cancer cell line T24 and can be utilized in cancer research[1].
Product Specifications
CAS Number
[2222067-12-9]
UNSPSC
12352211
Target
Ferroptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pro-ga.html
Purity
97.86
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(OC)CCCC(N[C@@H](C)C(OCOC(C)=O)=O)=O
Molecular Formula
C12H19NO7
Molecular Weight
289.28
References & Citations
[1]Hanada E, et al. Pro-GA, a Novel Inhibitor of γ-Glutamylcyclotransferase, Suppresses Human Bladder Cancer Cell Growth. Anticancer Res. 2019 Apr;39 (4) :1893-1898.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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