Hypophyllanthin

Hypophyllanthin is a major lignan in Phyllanthus spp, with strong anti-inflammatory activity. Hypophyllanthin directly inhibits P-glycoprotein (P-gp) activity and did not interfere with multidrug resistance protein 2 (MRP2) activity[1][2].

Product Specifications

CAS Number

[33676-00-5]

UNSPSC

12352005

Hazard Statement

H302

Target

P-glycoprotein

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/hypophyllanthin.html

Purity

98.84

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

COC[C@@H]1[C@@H](COC)CC2=CC(OC)=C(OCO3)C3=C2[C@H]1C4=CC=C(OC)C(OC)=C4

Molecular Formula

C24H30O7

Molecular Weight

430.49

Precautions

P264-P270-P330-P501

References & Citations

[1]Harikrishnan H, et al. Anti-Inflammatory Effects of Hypophyllanthin and Niranthin Through Downregulation of NF-κB/MAPKs/PI3K-Akt Signaling Pathways. Inflammation. 2018 Jun;41 (3) :984-995.|[2]Sukhaphirom N, et al. Phyllanthin and hypophyllanthin inhibit function of P-gp but not MRP2 in Caco-2 cells. J Pharm Pharmacol. 2013 Feb;65 (2) :292-9.