Hypophyllanthin
Hypophyllanthin is a major lignan in Phyllanthus spp, with strong anti-inflammatory activity. Hypophyllanthin directly inhibits P-glycoprotein (P-gp) activity and did not interfere with multidrug resistance protein 2 (MRP2) activity[1][2].
Product Specifications
CAS Number
33676-00-5
UNSPSC
12352005
Hazard Statement
H302
Target
P-glycoprotein
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hypophyllanthin.html
Purity
98.84
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
COC[C@@H]1[C@@H](COC)CC2=CC(OC)=C(OCO3)C3=C2[C@H]1C4=CC=C(OC)C(OC)=C4
Molecular Formula
C24H30O7
Molecular Weight
430.49
Precautions
P264-P270-P330-P501
References & Citations
[1]Harikrishnan H, et al. Anti-Inflammatory Effects of Hypophyllanthin and Niranthin Through Downregulation of NF-κB/MAPKs/PI3K-Akt Signaling Pathways. Inflammation. 2018 Jun;41 (3) :984-995.|[2]Sukhaphirom N, et al. Phyllanthin and hypophyllanthin inhibit function of P-gp but not MRP2 in Caco-2 cells. J Pharm Pharmacol. 2013 Feb;65 (2) :292-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
489571 100 µL
PSMA1 (Proteasome Subunit Alpha Type-1, Proteasome (Prosome, Macropain) Subunit, Alpha Type, 1)
Sign In for Pricing
View Details